"of course if you take several pills of x everyother weekend I wont deny that it will result in brain damage, but what kind of sane person would do that in the first place?" This comment displays a profound ignorance of the mechanisms of drug dependence as well as of the sociology of substance abuse. Unfortunately, none of us is "smart enough" or "sane enough" to be safe from the temptations -and the dangers- of drugs. Unfortunately, substance abuse does not necessarily indicate that the individual is "insane" to start with: it hits harder, for instance, in the poorer communities (like any disease). Being socially under-privileged does not mean being "insane".